In a large mixing bowl, combine the flaked salmon, breadcrumbs, chopped onion, chopped bell pepper, mayonnaise, egg, Dijon mustard, Worcestershire sauce, garlic powder, black pepper, and salt. Mix until all ingredients are well combined.
Shape the mixture into patties, about 2-3 inches in diameter. You should get around 8 patties.
Heat the vegetable oil in a large skillet over medium heat. Once the oil is hot, carefully add the salmon patties to the skillet, cooking in batches if necessary to avoid overcrowding.
Fry the patties for about 4-5 minutes on each side, or until they are golden brown and crispy. Remove them from the skillet and place them on a paper towel-lined plate to drain excess oil.
Serve the salmon patties warm with lemon wedges on the side.