Preheat your grill or stovetop skillet over medium-high heat.

In a large bowl, combine the ground beef, garlic powder, onion powder, Italian seasoning, salt, and pepper. Mix until just combined, being careful not to overwork the meat.

Divide the mixture into four equal portions and shape each portion into a patty.

Cook the patties on the grill or skillet for about 4-5 minutes on each side, or until they reach an internal temperature of 160°F.

During the last minute of cooking, spoon marinara sauce over each patty and sprinkle with mozzarella cheese and pepperoni. Cover the grill or skillet to melt the cheese.

Toast the hamburger buns on the grill or in a toaster until golden brown.

Assemble the burgers by placing each cheesy patty on a bun. Top with additional marinara sauce and fresh basil leaves if desired. Serve immediately.