Preheat your oven to 400°F. Line a baking sheet with parchment paper.
In a large bowl, combine the buttermilk, garlic powder, onion powder, smoked paprika, salt, and black pepper. Add the chicken thighs, ensuring they are fully submerged. Cover and refrigerate for at least 1 hour, or up to overnight for more flavor.
In a shallow dish, mix the flour and panko breadcrumbs together. Remove the chicken from the buttermilk mixture, allowing excess liquid to drip off. Dredge each piece of chicken in the flour and panko mixture, pressing gently to adhere.
Place the coated chicken on the prepared baking sheet. Drizzle the olive oil over the chicken to help it crisp up during baking.
Bake in the preheated oven for 25-30 minutes, or until the chicken is golden brown and cooked through (internal temperature should reach 165°F).
Remove the chicken from the oven and drizzle hot honey over the top while it’s still warm. Serve immediately.